Supplementing with DAOgest, a diamine oxidase (DAO) enzyme ingredient manufactured by Bioiberica, was associated with a reduction in allergy-like symptoms in a group of people with histamine intolerance in a single-arm observational study.
 
The study, which was published in Clinical Nutrition ESPEN, was presented for the first time at the ESPEN Congress on Clinical Nutrition and Metabolism, from September 11-14.
 
In the observational study, which involved 82 people with histamine intolerance, participants were administered 4.2 mg of the enzyme along with vitamin C and catalase daily for four weeks. The supplement was administered ahead of the participants’ main meal of the day, and the impact of histamine intolerance was evaluated using a standardized questionnaire at baseline, and then every week for the duration of the study. The questionnaire evaluated the intensity of impacts on the nervous system, gastrointestinal, respiratory, skin, and circulatory health.
 
By as early as one week into treatment, perceived GI and skin effect scores improved by over 90%, closely followed by nervous system and respiratory effects (80%) and then circulatory effects (38%).
 
“Histamine intolerance continues to be a prevalent yet largely unaddressed digestive health issue, and we’re committed to advancing research in the field for this very reason. The decision to conduct an observational study was driven by the complex nature of identifying individuals with the condition and the scarcity of robust studies examining the real-world effects of histamine intolerance solutions,” said Andrea Terradillos, R&D project manager at Bioiberica.
 
“We concluded that DAOgest supplementation at a low dose of 4.2 mg/serving daily helps to reduce the effects of histamine intolerance in just one week. Our advice for formulators in the space is to pair DAOgest with vitamin C, as it boosts the histamine degrading capacity of DAO and consequent histamine breakdown. In a separate investigation, we’ve provided evidence that this combination exhibits higher enzymatic activity compared to other commercially available DAO products.”