Metabolaid® aids weight management by promoting GLP-1 and AMPK activation, supporting appetite control, metabolic health, and gut health

Weight management continues to be a top priority for health-conscious consumers. Many are looking for natural, scientifically backed solutions that go beyond traditional methods such as diet and exercise. Botanical formulations that support both weight management and overall metabolic health are gaining traction1,2. One such solution is Metabolaid®, developed by Monteloeder by Suannutra, which has emerged as a promising option for individuals seeking to support their metabolism and weight management naturally. A key mechanism behind its efficacy is its ability to stimulate GLP-1, a hormone crucial in regulating appetite and blood sugar levels. This offers a comprehensive approach to achieving weight management goals, promoting metabolic health, and supporting overall wellness.

Metabolaid® combines polyphenol-rich extracts from lemon verbena and hibiscus, bringing together the benefits of both botanicals in a synergistic formulation. The research supporting this product spans over 20 years, supported by an EU’s funding programme for research and innovation (H2020 project), and validated through a series of clinical studies. These studies have demonstrated its effectiveness in various aspects of metabolic health, including its potential to support weight management, and metabolic health.

The Role of GLP-1 in Weight Management

Glucagon-like peptide-1 (GLP-1) is a hormone that plays a critical role in managing appetite and blood glucose levels. It is released in response to food intake and helps the body maintain stable blood sugar levels by promoting insulin secretion and inhibiting glucagon release. Additionally, GLP-1 slows down gastric emptying, which prolongs the feeling of fullness after meals and reduces the urge to snack between them. This makes GLP-1 a significant target for supporting healthy eating habits and weight management.

“Metabolaid® has been shown to naturally support GLP-1 levels by approximately 13% compared to a placebo⁷,” says Maria Ángeles Gutiérrez Montero, Marketing Director at SuanNutra. “This effect was observed within just 15 minutes of taking the supplement and lasted for over an hour, contributing to a feeling of fullness and helping consumers control their appetite more effectively.”

By supporting GLP-1 secretion, Metabolaid® offers an innovative way to help individuals reduce their overall caloric intake and maintain healthier eating patterns. This support can be a valuable tool in a weight management program, helping to address hunger and cravings.

Cardiovascular and Metabolic Health Support

In addition to its role in weight management, Metabolaid® has demonstrated significant cardiovascular benefits. Excess body fat, particularly around the abdomen, is linked to an increased risk of cardiovascular disease, high blood pressure, and other metabolic conditions. By promoting weight loss and improving body composition, Metabolaid® may help reduce these risks, but its effects extend further into direct support for heart health.

Clinical studies have shown that Metabolaid® can help maintain healthy blood pressure levels within the normal range. One such study, involving participants with pre-hypertension, demonstrated that daily supplementation with Metabolaid® led to a significant reduction in both systolic and diastolic blood pressure. “This is likely linked to Metabolaid®‘s ability to activate the AMPK pathway, which helps regulate energy balance and reduce oxidative stress, both of which are crucial for maintaining healthy blood vessels and cardiovascular function,” ^8,9,10,11 explains Karin Hermoni, Vice President, Science & Innovation at Suannutra.

In addition to supporting healthy blood pressure, Metabolaid® has also been shown to influence cholesterol levels positively. It helps maintain a healthy balance between LDL (“bad”) cholesterol and HDL (“good”) cholesterol, which is essential for cardiovascular health.

Mechanism of Action: AMPK Activation for Metabolic Support

A key mechanism by which Metabolaid® supports weight management and metabolic health is through the activation of the adenosine monophosphate-activated protein kinase (AMPK) pathway. AMPK is often referred to as the body’s “energy sensor” because it helps regulate energy balance at the cellular level. When activated, AMPK promotes the burning of stored fat for energy and inhibits the production of new fat cells, which contributes to weight loss and metabolic health.

“One of the groundbreaking aspects of Metabolaid® is the synergistic effect of lemon verbena and hibiscus extracts on AMPK activation,” says Jonathan Jones, Chief Scientific Officer at Monteloeder by Suannutra. “We observed a six-fold increase in AMPK activation when using the combination of these extracts compared to individual extracts, significantly enhancing fat burning and energy metabolism.”⁶

AMPK activation supports metabolic fitness by enhancing the breakdown of fats and sugars for energy, reducing fat storage, and improving insulin sensitivity. By increasing AMPK activity, Metabolaid® helps the body become more efficient at using its stored energy, which is particularly beneficial for those looking to manage their weight.

Gut Health and the Microbiome

In recent years, the connection between gut health and weight management has garnered increasing attention. A well-balanced gut microbiome is essential for maintaining a healthy metabolism and regulating body weight. Certain bacteria in the gut are known to influence nutrient absorption and fat storage, making the microbiome an important factor in overall metabolic health.

Research suggests that Metabolaid® may have a positive impact on the gut microbiome by promoting the growth of beneficial bacteria. Its polyphenols—such as anthocyanins and verbascosides—are metabolized by gut bacteria into active compounds that help regulate the microbiome. “These compounds promote the growth of beneficial bacteria such as Akkermansia, Blautia, and Prevotella, which are associated with better weight control and insulin sensitivity⁵” says Hermoni.

Moreover, Metabolaid® increases the production of short-chain fatty acids (SCFAs), such as butyric acid, which are known for their role in maintaining the integrity of the gut lining and supporting overall digestive health. SCFAs play a key role in reducing inflammation and promoting a healthy gut environment, which further contributes to better metabolic health.

By promoting a healthy microbiome, Metabolaid® not only supports weight management but also enhances overall metabolic function. A healthy gut is essential for efficient digestion, blood sugar control, and appetite regulation, all of which are critical factors in long-term weight management.

Weight Management Support

One of the standout features of Metabolaid® is its ability to support weight management without the need for drastic lifestyle changes. Clinical trials have shown that participants who took Metabolaid® experienced significant reductions in body weight, body fat, and waist circumference. These results were observed when Metabolaid® was used alongside a balanced diet and regular exercise, supporting its role as part of a comprehensive weight management strategy.

In one study, participants who combined Metabolaid® with a moderate diet and exercise plan lost an average of 4kg and reduced their waistlines by 6cm over two months. “Metabolaid® can help consumers on their weight management journey by supporting appetite regulation and metabolism,” says Gutiérrez Montero. “Its ability to promote a feeling of fullness and reduce cravings can make it easier for people to stick to their healthy eating plans.”

Additionally, Metabolaid® addresses one of the key challenges in long-term weight management: the tendency for the body to regain weight after a period of caloric restriction. This phenomenon, known as the “energy gap,” occurs when the body compensates for reduced food intake by increasing hunger and reducing energy expenditure.

“Metabolaid® is designed to help consumers navigate this difficult phase by promoting appetite-suppressing hormones like GLP-1 and leptin while reducing hunger-stimulating hormones like ghrelin,” explains Hermoni. “This balance can help mitigate the challenges of rebound weight gain, making long-term weight maintenance more achievable.”

Conclusion: A Holistic Approach to Weight and Metabolic Health

With its scientifically validated mechanisms of action and a solid track record in clinical studies, Metabolaid® offers a comprehensive, natural solution for those looking to manage their weight and support their metabolic health. By stimulating GLP-1 and activating AMPK, Metabolaid® addresses both the immediate challenges of weight management and the broader issues of metabolic and cardiovascular health.

Furthermore, its positive impact on gut health provides another layer of support for long-term weight management and overall wellness. A healthy gut microbiome, combined with enhanced metabolic fitness and appetite regulation, makes Metabolaid® a well-rounded option for individuals seeking a sustainable, natural approach to their weight management goals.

Backed by over 20 years of research and development, Metabolaid® continues to lead the way in natural solutions for weight management, offering consumers a safe and effective option to support their overall health.

References ​

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