An in vitro study published in the Journal of Biochemistry and Physiology found that a juice-based delivery format appeared to improve the survival rate of probiotics against stomach acid compared to a dry powder format. Specifically, the study used a formulation of Doctor’s Biome Signature Probiotic Blend, which contains five Bifidobacterium strains and ten Lactobacillus strains. The carrier was a sterilized blend of organic green juices.

A few years ago, Dr. Howard Robins, DPM, chief medical officer of Doctor’s Biome, anecdotally observed that juice-based, living probiotics appeared to offer more efficacy than those in dry powder. Reza Kamarei, PhD, chief science and technology officer of Doctor’s Biome, theorized that juice-based delivery formats could ensure greater survivability of living probiotics against stomach hydrochloric acid, the company reported. In the in vitro study, each formulation was exposed to a highly acidic environment, and, according to the authors, the juice-suspended probiotics survived and formed colonies, while those in a dry powdered form didn’t.

According to an anonymous reviewer of the study from the Journal of Biochemistry and Psychology, the findings present “compelling evidence that pre-hydrating dry powder probiotics in a fruit and vegetable juice carrier significantly improves their survival rate in acidic conditions, such as those in the stomach. By comparing this juice-based delivery method to traditional dry powder formulations, the researchers highlight the positive impact of hydration, buffering, and glucose metabolism on probiotic efficacy. This innovative approach, designating such blends as ‘next generation probiotics,’ suggests promising applications for improving health outcomes associated with probiotic supplements. The study’s design and results are both informative and encouraging.”

“The exciting results of this study, which confirm the patent-pending superiority of our juice-based dietary supplements and medical foods, validate my initial decision to invest in Doctor’s Biome. I am proud to see that our company’s mission to be the leader in juice-based, clinically-validated probiotics, is being realized,” said Richard Finkelstein, CEO of Doctor’s Biome.