Every day, our brains process countless pieces of information, control our actions, and manage our emotions. But as we age or face high-stress situations, our brain’s efficiency can decline. With the rise in interest in cognitive health supplements, DavosLife E3 Tocotrienols stand out for their ability to support mental sharpness, preserve cognitive function, and even aid in brain recovery. This article explores how these natural Tocotrienols can benefit individuals at different stages of life, backed by scientific research.

Comprehensive Cognitive Support

Our brain, the control centre of the body, manages everything from our thoughts and actions to our feelings and bodily functions. However, its high demand for oxygen makes it particularly vulnerable to oxidative stress, which can lead to inflammation, mitochondrial dysfunction, and even amyloid beta protein aggregation—a key factor in dementia. These issues aren’t just limited to older adults; young adults can also experience reduced focus, attention, and memory due to oxidative stress and chronic inflammation.

There is interest in brain-boosting products from these different groups of consumers, but they are seeking different benefits from these supplements. Young and healthy adults want products that optimise mental performance in terms of focus, attention and cognitive speed. The elderly want products that preserve brain health – they want to maintain mental sharpness as they age, and they also want products that support brain recovery from cognitive issues such as stroke.

Tocotrienols are powerful lipid-soluble antioxidants with potent neuroprotective effects. They are members of the Vitamin E family, and are highly bioavailable to the brain. Tocotrienols have additional anti-inflammatory and gene modulation properties, and these three key properties provide comprehensive brain health support, meeting the needs of these different groups of consumers.

Optimise Mental Performance

In today’s fast-paced world, young adults, particularly those from Gen Z, are under constant pressure to perform at their best. They live in a fast-paced world, where the expectation is to constantly hustle and work hard. For Gen Z, having a brain that is fine-tuned for performance means mental sharpness, fast memory recall, and being able to multitask while keeping focus. These are seen to be critical for success in today’s world.

Recent research published in the Journal of Functional Foods by Neo et al. (2024) highlights that DavosLife E3 Tocotrienols had significant impact on neuron cell growth and communication, key factors in memory formation, attention, and neural efficiency. The study revealed that DavosLife E3 Tocotrienols promoted neuron cell growth by increasing cell division and enhancing key proteins (Cyclin D1 and E1). It also activated the BDNF/TrkB signalling pathway, which is vital for neuron generation and synapse regulation. This pathway, along with the MAPK/ERK and PI3K/Akt pathways, supports the growth and functionality of neuron cells. DavosLife E3 Tocotrienols enhanced synaptic responses, by increasing the phosphorylation of proteins like CaMKII and GluA1. These proteins are involved in boosting long-lasting synapse responses, a process essential in learning and memory. This leads to improved reaction times and neural efficiency, which boosts mental sharpness and fast memory recall.

These observations are supported by a clinical study on DavosLife E3 Tocotrienols by Par et al. (2022) in the Journal of Functional Foods, showing that the daily intake of 200mg Tocotrienols resulted in significant improvement in subjects’ memory relative to their baseline in as little as 2 weeks, as measured by higher average mean span for both forward (23.2%) and reverse Digit Span Test (23.7%). Subjects supplemented with DavosLife E3 Tocotrienols showed 44.3% faster reaction than compared to placebo, as assessed by Psychomotor Vigilance Test. DavosLife E3 Tocotrienols supplementation led to a marked reduction of alpha and low-beta power compared to baseline, suggesting that it enhances neural efficiency.

Preserve Brain Health

As life expectancy increases, so does the importance of preserving cognitive function. For older adults, maintaining brain health is crucial for functional independence and quality of life. One of the hallmarks of dementia, including Alzheimer’s disease, is the aggregation of amyloid beta peptides and the resulting neuroinflammation.

Research by Ibrahim et al. (2017) that were published in the Journal of Alzheimer’s Disease revealed that Tocotrienols dose-dependently modulated amyloid beta aggregation. Tocotrienols reduced amyloid beta oligomers, inhibiting the formation of high molecular weight amyloid beta aggregates, eventually reducing amyloid beta fibrillization in vitro, thus reducing its cytotoxic effects. This finding was further corroborated with an animal study which showed that Tocotrienols supplementation reduced the numbers of plaques in the hippocampus and cortex.

A prospective cohort study of Finnish older adults (aged 65 and above), published by Mangialasche et al. (2013) in Experimental Gerontology, found that higher serum levels of Tocotrienols were associated with a reduced risk of dementia. This suggests that Tocotrienols play a protective role in maintaining brain health as we age.

Support Brain Recovery

Stroke is a devastating condition that disrupts blood flow to the brain, leading to oxygen deprivation and neuron cell death. This cell death can result in severe disabilities, affecting millions worldwide each year.

Research by Khanna et al. (2010) in the Journal of Neurochemistry demonstrated that Tocotrienols prevent neuron cell death by inhibiting cytosolic calcium-dependent phospholipase A2 (cPLA2), an enzyme that releases arachidonic acid into the brain, triggering neuron cell death. Tocotrienols were shown to reduce arachidonic acid levels by up to 60%, offering significant neuroprotection.

Tocotrienols could also help to rescue the brain after stroke injury. Studies by Rink et al. (2011) in the Journal of Cerebral Blood Flow and Metabolism showed that Tocotrienols activated arteriogenesis to increase the diameter of existing arteries in response to oxygen demand, thereby offering collateral blood supply to reduce brain damage. 

Leading Nootropic for Every Age

Consumers young and old worry about their brain health today, leading to a growing demand for nootropic supplements to meet these needs. Research findings show that DavosLife E3 Tocotrienols are a promising nootropic to cater for cognitive needs through the ages as it can optimise mental performance, preserve brain health and support brain recovery. DavosLife E3 Tocotrienols has clinically proven efficacy in young and healthy adults (aged 20 – 25 years), in as little as 2 weeks with a minimal daily dose of 200 mg/day, setting it apart from other nootropics on the market.

In summary, DavosLife E3 Tocotrienols offer a unique and scientifically validated solution for cognitive health. Whether you’re a young adult looking to enhance mental performance, an older individual aiming to preserve brain function, or someone recovering from a stroke, these Tocotrienols provide comprehensive support tailored to your needs. With proven efficacy and a strong safety profile, DavosLife E3 Tocotrienols are positioned as a leading choice in the growing market of brain health supplements.

About DavosLife E3 Tocotrienols

DavosLife E3 Tocotrienols is a natural Vitamin E, rich in the full spectrum of Tocotrienols and α-Tocopherol. Available in both liquid and powder forms, it caters to a variety of applications in nutraceuticals, functional foods, beverages, and personal care. Derived from non-GMO palm fruits sourced from RSPO-certified plantations, and manufactured in an RSPO-certified facility, DavosLife E3 Tocotrienols meets all major international standards on contaminants in health supplements.

About Davos Life Science

Davos Life Science, a subsidiary of Kuala Lumpur Kepong Berhad (KLK), is a global leader in producing high-quality natural phytonutrients. Integrated with KLK’s plantations and resource manufacturing division, KLK OLEO, Davos Life Science ensures a reliable supply of DavosLife E3 Tocotrienols and DavosLife Biocarotene Palm Mixed Carotenes.