Researchers at Wayne State University have conducted preliminary research that suggests grape skin extract (GSE) may yield an inhibitory effect on hyperglycemia. It is anticipated that this research could be used to manage diabetes, which currently affects approximately 26 million people in the U.S.
 
Recently funded by the National Center for Complementary and Alternative Medicine of the National Institutes of Health, this $2.1 million transitional study aims to provide insights into the novel inhibitory action of GSE on postprandial hyperglycemia and will also provide preclinical data in support of the biological effectiveness and safety of GSE and its components in potential prevention and treatment of type 2 diabetes.
 
“It is hopeful that our research may eventually lead to the successful development of a safe, targeted nutritional intervention to support diabetes prevention and treatment,” said Kequan Zhou, Ph.D., assistant professor of food and nutrition science in the College of Liberal Arts and Sciences, and lead investigator on the grant. “Our study will provide important pre-clinical data regarding the anti-diabetic mechanisms, biological efficacy and safety of GSE that should facilitate eventual translation into future clinical studies to assess GSE and its components as a safe, low-cost and evidence-based nutritional intervention for diabetes.”
 
Type 2 diabetes is the most common form of diabetes. With type 2 diabetes, the body does not produce enough insulin or the cells ignore the insulin. In addition, some groups have a higher risk for developing type 2 diabetes, including African Americans, Latinos, Native Americans, Asian Americans/Pacific Islanders, and the elderly.
 
“Type 2 diabetes is one of the major chronic diseases of modern societies,” said Gloria Heppner, Ph.D., associate vice president for research at Wayne State University. “It threatens the health of a variety of populations, with growing numbers of young people being diagnosed with the disease every day. Dr. Zhou’s study offers great hope for a potential treatment that is natural and without harmful side effects for the many people inflicted with type 2 diabetes.”
 
The grant number for this National Institutes of Health research project is AT007566.