AIDP presented peer-reviewed research recently published in the medical journal, Neuropharmacology, which explains the mechanism through which threonates work, and how it increase the amount of magnesium in the brain when subjects were administered magnesium L-threonate, the ingredient marketed into the dietary supplement market under the trade name Magtein. More importantly, it shows that threonate is the only ligand to efficiently transport magnesium to neuron cells in the brain. Until now, while prior clinical research has substantiated this process, this recent body of work further explores the intricate process through which Magtein is transmitted through the brain, crossing the blood brain barrier.
 
The paper is titled “Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration.” It identified the molecular mechanism of action for Magtein, further confirming the results of previous human clinical studies.
 
The current study provides a scientific explanation for how Magtein works. The study concluded that intraneuronal magnesium is a critical regulator of synaptic density and plasticity, critical factors that determine cognitive ability. In this paper, L-threonate, the unique component of the Magtein, drove magnesium into the fluids that surround the brain (cerebrospinal fluid), and then into neurons. This lead to multiple changes including enhanced synaptic density and plasticity, as supported by human clinical study. In addition, increased brain magnesium levels have been shown to support restful sleep and balanced mood. Other magnesium salts lacking L-threonate failed to have the same results.
 
“This new body of research is ground-breaking in that it explains at the molecular level why Magtein is so effective in cognitive function,” states Jennifer Gu, PhD, chief science officer at AIDP. “Magnesium l-threonate is the only compound effectively transporting magnesium to the brain. Moreover, this paper also suggests that other minerals beneficial to the brain and neuron cells, such as zinc and selenium, can also be efficiently transported using this patented carrier to support brain function. This opens doors for formulations and other brain beneficial minerals.”
 
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