An in vitro study conducted by the Eurecat Technology Center, a leading research company in Catalonia, found that Euromed’s Pomanox pomegranate extract may reduce hyperpigmentation, attenuate oxidative stress induced by excessive UV radiation, promote the maintenance of skin strength, and ameliorate skin dryness (Eurecat Technology Centre, 2020).
 
By using in vitro models, the researchers aimed to investigate the possible beneficial effects of Pomanox on skin health. In particular, they evaluated the extract’s capacity to modulate collagen and hyaluronic acid metabolism, protect against skin aging caused by UV radiation and inhibit tyrosinase activity—an enzyme that catalyzes the production of melanin in the skin.
 
Researchers found the tyrosinase-inhibiting effect of Pomanox is comparable to that of commercial tyrosinase inhibitors, such as thiazolidine. Thus, it can reduce hyperpigmentation by decreasing melanin synthesis. In addition, pomegranate is a rich source of polyphenols, which have antioxidant properties and inhibit pro-inflammatory enzymes, as confirmed by the study. Therefore, Pomanox has the potential to counteract oxidative stress caused by excessive exposure to UV radiation.
 
It was also found that Pomanox may help improve skin dryness caused by UV rays, by positively modulating hyaluronic acid and collagen metabolism in photoaging conditions.
 
Pomanox may also help maintain skin elasticity through modulation of collagen metabolism, as demonstrated by the increase of pro-collagen type I and total collagen in the cell fraction, and a significant inhibition of MMP-1 levels, the main inhibitor of collagen synthesis. Inhibition of MMP-1 is also an area of interest for patients with rheumatoid arthritis.
 
Pomanox is a natural standardized pomegranate fruit concentrate obtained from pomegranates cultivated in Mediterranean regions of Spain through sustainable farming, according to Euromed. It is available in organic form, and extracted with an eco-friendly, water-only proprietary technology.