Oral ATP supplementation is associated with significantly greater exercise-induced muscle mass and strength gains compared to placebo, according to a recent review published in Sports.
 
ATP is a highly bioavailable energy source, providing energy for all cells in the human body. Clinical studies provide evidence that supplementation with this compound can boost muscle power output and improve blood flow.
 
“We are gratified to have the scientific community affirm the relevance and quality of our research,” said Shawn Baier, vice president of business development for TSI’s Innovative Products Division. The present review relied heavily on studies evaluating the efficacy of TSI’s branded ATP ingredient, Peak ATP. “This meta-analysis comes at a time when there is a resurgence of interest in PEAK ATP, as more and more brands throughout the world are looking to provide their customers with the best pre workout ingredient for real energy and real results.Numerous studies confirm its immediate benefits for athletes, weekend warriors and everyday exercisers.”
 
First of its Kind
 
The present review and systematic analysis is the first of its kind to look at data on the effects of ATP supplementation in anaerobic performace. Variables included maximal strength, maximum repetitions, and maximum aerobic power in healthy, resistance-trained subjects.
 
The authors focused on studies from 2000 to 2022, narrowing their selection to five published human clinical studies, four of which used Peak ATP. Each was a double-blind, randomized, controlled trial with a high methodological quality.
 
In addition to confirming that oral ATP supplementation induced greater maximal strength gains than the placebo, the systematic review and meta-analysis confirmed that daily intakes of 400 mg of ATP for periods up to 12 weeks are safe in healthy subjects.
 
The five selected studies included:
 

• Jordan, et al. (2004): This study found that, in 27 healthy males, ATP supplementation was associated with improved 1RM and repetitions to fatigue in the high-dosage group, as well as total lifting volume. While not clinically significant, the authors concluded that oral ATP supplementation “may provide small ergogenic effects on muscular strength under some treatment conditions.”
• Wilson, et al (2013):Results of this study showed that PEAK ATP increased strength (147% increase over placebo), increased power (30% increase over placebo), increased lean body mass (100% increase over placebo), and increased muscle thickness (96% increase over placebo).
• Purpura, et al 2017: This study, involving a repeated sprint exercise test, found that PEAK ATP increased participants’ post-exercise ATP levels, muscle excitability, and sprint performance following a repeated sprint bout.
• Freitas, et al 2019: The study found a single dose of PEAK ATP improved lower-body resistance training performance and energy expenditure.
• Dos Santos, et al 2021: This study concluded that a single 400 mg dose of PEAK ATP improved lower body resistance training performance and energy expenditure in recreational resistance-trained participants.