Supplyside West

Booth #3827

Prolanza, a proprietary, sustained-release extract of ashwagandha root (Withania somnifera (L.) Dunal), has been shown to be safe, well tolerated, and effective in managing stress in healthy adults, according to a study published in Evidence-Based Complementary and Alternative Medicine.

The ingredient, from Nutriventia by Inventia, a global leader in novel delivery solutions, also has a published study which showed Prolanza provided superior levels of bioactives in human plasma compared to other ashwagandha ingredients.

Nutriventia’s release of its latest clinical study (which was published late 2021) was consciously held back earlier to allow it to coincide with the launch of the ingredient at SupplySide West 2022.

“Because Nutriventia, Inventia Healthcare's health and wellness brand, is at the cusp of science and nature, we wanted to be absolutely sure we could release the results of the Prolanza study without any hiccups,” said Anand Godbole, Nutriventia vice president of marketing. “We now have two Prolanza studies that have shown positive results and feel manufacturers will quickly utilize our branded ingredient in their formulations.”

New Study Details

The prevalence of stress continues to rise steadily around the world. Stress adversely impacts cognitive ability, sleep quality, and overall psychological wellbeing. Ashwagandha, an essential botanical remedy in Ayurveda, is considered beneficial in reducing stress and improving memory, study authors noted.

This randomized, double-blind, placebo-controlled 90-day clinical study evaluated the effect of 300 mg Prolanza ashwagandha root extract sustained-release capsule on cognitive functions, stress levels, sleep quality, overall wellbeing, and safety in 125 adult participants reporting high stress levels.

In the Prolanza group, the Cambridge Neuropsychological Test Automated Battery (CANTAB) showed significantly improved recall memory, and the total error rate in recalling patterns significantly decreased at visit 4.

At visit 4, reduced Perceived Stress Scale (PSS) score, serum cortisol levels, and Pittsburgh Sleep Quality Index (PSQI) score but higher Oxford Happiness Questionnaire (OHQ) scores were seen in the supplement group vs. the placebo group, suggesting significantly lower stress levels and markedly improved psychological well-being and sleep quality in the former. No adverse events were reported.

Results and Conclusions

The study authors concluded that supplementing with one 300 mg ashwagandha sustained-release capsule daily for 90 days improved memory recall, psychological wellbeing, sleep quality as well as reduced stress levels. As no adverse events were reported, Prolanza was also found to be safe and well-tolerated.

“The results of this study illuminate why ashwagandha is known as the stress-busting adaptogen,” said Godbole. “Further, consumers who are seeking noticeable reductions in stress response will appreciate Prolanza’s sustained-release delivery, which increases the duration of its effects, safely.”

The journey at Inventia began almost four decades ago, when two scientists with deep-rooted knowledge in medical sciences, ventured out to develop solutions that were an improvement on generic products becoming the pioneers of NDDS products in India. Today, Nutriventia is a preferred partner to multinational and Indian transnational companies for their global requirements. Nutriventia uses proprietary and patented processes to improve ingredients by addressing issues and concerns in manufacturing, formulation, clinical research.