Research

Multivitamin Use May Reduce CVD Risk Among Men

Researchers analyzed healthy male physicians from the Physicians’ Health Study I cohort.

Healthy men who take multivitamins for 20-plus years may lower their risk of cardiovascular disease (CVD), according to a long-term prospective study published in the Journal of Nutrition.

Although multivitamins are widely used by U.S. adults, few prospective studies have investigated their association with the long- and short-term risks of CVD. This study investigated how multivitamin use may be associated with the risk of CVD in initially healthy men at baseline.

SCROLL TO CONTINUE


Researchers studied 18,530 male physicians aged ≥40 years from the Physicians’ Health Study I cohort who were free of CVD and cancer at baseline (1982). All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected foods and dietary supplements. Cox proportional hazards models were used to calculate multivariable-adjusted HRs (95% CIs).

During a mean follow-up of 12.2 years (total of 225,287 person-years), there were 1,697 incident cases of major CVD (defined as non-fatal myocardial infarction, non-fatal stroke and CVD death). In multivariable-adjusted analyses, no significant associations were observed among baseline multivitamin users compared with non-users for the risk of major CVD events (HR: 0.94; 95% CI: 0.84, 1.05), whereas a self-reported duration of ≥20 years at baseline was associated with lower risk (HR: 0.56; 95% CI: 0.35, 0.90; P-trend = 0.05). Baseline multivitamin use was also significantly inversely associated with the risk of cardiac revascularization (HR: 0.86; 95% CI: 0.75, 0.98). Baseline use of multivitamins was not significantly associated with other CVD endpoints.

Researchers concluded that in this long-term prospective study of initially healthy men, multivitamin use for ≥20 years was associated with a lower risk of major CVD events.

Keep Up With Our Content. Subscribe To Nutraceuticals World Newsletters