Life Extension, Fort Lauderdale, FL, has partnered with Insilico Medicine, Baltimore, MD, to identify specific nutrient combinations that function as geroprotectors, or agents capable of extending a healthy lifespan. The objective is to develop innovative ways to support healthy aging.

To that end, Life Extension is introducing Ageless Cell, the first supplement in its GeroProtect line. The product delivers unique ingredients that inhibit cellular senescence, a natural part of the aging process where cells no longer function optimally.

“By rejuvenating near-senescent cells and encouraging the body’s healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level,” said Michael Smith, MD, senior health scientist for Life Extension.

This scientific collaboration has resulted in the identification of a geroprotector formulation consisting of four nutrients with various complementary and reinforcing properties. “Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets,” said Andrew Swick, PhD, senior vice president of product development and scientific affairs for Life Extension.

Scientists from Life Extension and Insilico Medicine worked together to identify a subset of four specific nutrients—myricetin, NAC, gamma tocotrienol, and EGCG—all of which modify senescence-inducing pathways, inhibiting the development of senescent cells.

The scientists found that the four nutrients work together, but in very different ways, to beneficially influence key anti-aging pathways. Together, they combat numerous aging factors throughout the body. These compounds all modulate specific biological pathways responsible for keeping people young and healthy. 

“Combined, these ingredients promote anti-aging mechanisms at the cellular level throughout the body, acting by multiple pathways, some unique, and some overlapping,” said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. “Together, these four natural compounds represent the beginning of the future—anti-aging cocktails identified using artificial intelligence under expert human supervision.”