In an era where scientific breakthroughs are reshaping our understanding of human health, the pursuit of longevity has emerged as a focal point of research and innovation.

Aging is a complex process shaped by genetics, lifestyle, and environment. Researchers are finding ways to slow aging and extend both lifespan and health span — the years lived in good health. This pursuit, called cracking the longevity code, involves understanding aging mechanisms like inflammation, oxidative stress, mitochondrial function, and cellular repair, and optimizing these processes.

Understanding Inflammaging: The Silent Driver of Aging

A key aspect of cracking the longevity code is addressing inflammaging. This chronic inflammation accelerates aging and increases the risk of diseases like cardiovascular issues, neurodegenerative disorders, and metabolic dysfunction. While lifestyle choices such as diet, exercise, and sleep are crucial for combating inflammaging, dietary supplements can further support by providing essential nutrients and bioactive compounds that enhance cellular longevity.

To crack the longevity code, mitigate inflammaging with lifestyle changes, diet, and interventions that support the body’s healing mechanisms.

The Role of Dietary Supplements in Longevity

Nutraceuticals backed by clinical research and actual science can complement a healthy lifestyle by targeting the biological pathways associated with aging. Here’s how they help in cracking the longevity code.

Reducing Inflammaging and Oxidative Stress

Inflammaging results from chronic inflammation and oxidative damage from free radicals. Some supplements have strong anti-inflammatory and antioxidant properties that combat these effects.

• Curcumin (HydroCurc®): Clinically proven as a potent anti-inflammatory, curcumin inhibits aging-related inflammatory pathways. HydroCurc® is a cold-water dispersible Curcuma longa extract designed to enhance curcuminoid absorption, addressing bioavailability challenges. It offers the highest bioavailability in a single dose.
• Palmitoylethanolamide-PEA (Levagen®+) is a naturally occurring fatty acid amide produced in response to injury and stress. Levagen®+ uses a patented LipiSperse® system to address traditional dispersion issues of PEA, enhancing its bioavailability and functionality. It is absorbed within 45 minutes, with 1.75 times the absorption of
  standard PEA.
• Resveratrol (VeriSperse®) activates sirtuins — proteins that enhance cellular health and longevity while reducing inflammation — but faces bioavailability issues. VeriSperse® is a cold water dispersible (CWD) trans-resveratrol powder, using LipiSperse® technology to provide double the bioavailability of standard resveratrol.
• Coenzyme Q10 (AquaCelle® CoQ10) is an antioxidant that supports mitochondrial function and reduces oxidative stress in the heart and brain. Designed for enhanced bioavailability and stability of ubiquinone CoQ10, AquaCelle® CoQ10 matches or surpasses the bioavailability of commercial ubiquinol. Clinical tests show it boosts CoQ10 uptake by over 300%.
• Omega-3 Fatty Acids (AquaCelle® Omega-3): Found in fish, krill, and algae, omega-3s reduce inflammation and support heart and brain health. AquaCelle® Omega-3 enhances DHA and EPA bioavailability and is clinically proven to improve absorption, increasing omega-3 uptake by over 600%.

Cardiovascular Health: Keeping the Heart Young

Heart disease is a leading cause of death globally, making cardiovascular health vital for longevity. Chronic inflammation leads to arterial stiffness, plaque buildup, and poor blood circulation, raising the risk of heart attacks and strokes. To promote cardiovascular health and counteract inflammaging, consider adding the following supplements that support heart health:

• Omega-3 Fatty Acids (AquaCelle Omega-3): as described above.
• Magnesium: It is crucial for more than 300 enzymatic reactions in the body. It helps regulate blood pressure and improve arterial flexibility.
• Vitamin K2 (PlexoZome®K2): Vitamin K2 is believed to direct calcium away from arteries and into bones, reducing the risk of arterial calcification. PlexoZome® is a scientifically proven complex liposomal technology verified through TEM and Cryo-TEM imaging, Zeta potential, and DLS test g.
• Saffron (Affron®) may modulate neurotransmitters like serotonin, dopamine, and noradrenaline, regulating mood and emotions. Affron® is a premium saffron standardized to 3.5% Lepticrosalides™. Nine clinical studies support its effectiveness in enhancing mood and alleviating occasional sleeplessness in healthy individuals facing stress.

Enhancing Cognitive Function and Brain Longevity

Neuroinflammation and oxidative damage contribute to cognitive decline. Certain supplements can protect the brain and enhance mental clarity and health:

• Curcumin (HydroCurc®): HydroCurc® with Ferrous Sulphate reduces oxidative stress and inflammation. Additionally, supplementing HydroCurc® with iron significantly increases serum Brain-Derived Neurotrophic Factor (BDNF) levels, crucial for neuronal health.
• Palmitoylethanolamide – PEA (in the form of Levagen®+): Levagen®+ supported significant improvement in serum BDNF levels and helped to improve memory through better first success and fewer errors.
• Salidroside (LANDKIND®Pure Salidroside) is a phenolic glycoside in Rhodiola rosea. It offers various health benefits: as an adaptogen for stress, fatigue resistance, neuroprotection, and antioxidant and anti-inflammatory effects. Crafted through fermentation, LANDKIND® Pure Salidroside provides a sustainable source of high-quality Rhodiola with consistent purity, supported by clinical research.
• Phosphatidylserine (PS): A phospholipid that improves memory and cognitive function.
• N-acetylcysteine (NAC) is a precursor to glutathione, the body’s most potent antioxidant, protecting the brain from oxidative damage.

Optimizing Metabolic Health and Energy Production

Metabolic dysfunction is a significant factor in aging. Maintaining stable blood sugar levels, insulin sensitivity, and mitochondrial efficiency is crucial
for longevity:

• Berberine (BioBerb®): Berberine is a compound found naturally in many plants. Some research suggests that it may help promote weight loss, enhance blood sugar regulation, improve heart health, and could aid in the treatment of depression and nonalcoholic fatty liver ailments. BioBerb® is Berberine with LipiSperse®, increasing its bioavailability and uptake in the body.
• Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Boost NAD+ levels, a coenzyme essential for cellular energy, DNA repair, and longevity. As we age, NAD declines, and so does our ability to maintain sufficient strength and vitality.

Promoting Cellular Repair and Longevity Pathways

Aging is associated with cellular damage, reduced autophagy (the body’s natural recycling process), and shorter telomeres (protective caps on DNA). Supplements that enhance cellular repair include:

• Quercetin (LipiSperse® Quercetin): A powerful antioxidant that supports cellular resilience and longevity. Increasing Quercetin’s normally limited absorption/bioavailability through LipiSperse® dispersion technology exponentially increases this super antioxidant’s power.
• Collagen Peptides (PlexoZome® Collagen): Support skin, joint, and connective tissue health by promoting collagen synthesis. Scientifically validated genuine liposomal Collagen with targeted delivery and improved stability.

Cracking the longevity code requires a holistic approach that optimizes diet, exercise, sleep, and stress management, targeting biological pathways with supplements.

While no single supplement guarantees a longer life, combining scientifically backed nutrients enhances health span by reducing inflammaging, supporting cardiovascular and cognitive function, optimizing metabolic health, and promoting cellular repair.

By integrating the right supplements with a healthy lifestyle, we can slow aging and extend our lifespan and, more importantly, our health span.

References

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7. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://cdn.prod.website-files.com/5f85d0c81b6f5da2719b6b03/646def583ce3ea4eea5ab473_Gencor%20PlexoZome%20Sell%20Sheet%202023.02.01.pdf 
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